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      • 科研項目及研究進展

      • 發布日期:2022/1/20    選擇字號:   

            (1)連續擴展創傷重點超聲評估技術在基層創傷救治中的推廣應用連鴻凱,2021年鄭州市惠民計劃項目

        2)三七總皂苷調控TLR4-NF-KB和NLRP3炎性體信號通路對急性軟組織損傷的保護作用(連鴻凱,2021年河南省高等學校重點項目

        3NF-kB調節棕色脂肪細胞的作用 (葉建平,鄭州大學人才啟動項目)

            (4)丁酸鈉調節棕色脂肪發育的跨代遺傳作用 (葉建平,科技部項目)

          (5IGF2BP2-m6A-CHMP5誘導血管細胞凋亡促進腦動靜脈畸形破裂出血的分子機制研究(王林建,2021年國自然青年項目)

          (6)線粒體生物發生參與多囊卵巢綜合征發病機制的研究(羅曼,2021年河南省科技攻關聯合共建項目)

          (7)用單細胞核測序的方法確定乳腺癌相關脂肪組織的細胞圖譜(湯麗娜,2021年河南省科技攻關聯合共建項目)

          (8)誘導脂聯素特異性異構體加快腎臟缺血再灌注損傷后的修復(金小高,2021年省重點研發與推廣專項(科技攻關)項目)

            主要發表科研論文如下:

        1. Lu, B. and J. Ye, Commentary: PROTACs make undruggable targets druggable: Challenge and opportunity. Acta Pharmaceutica Sinica B, 2021. 11(10): p. 3335-3336.(IF=11.5)

        2. Le J, Fu Y, Han Q, Wei X, Ji H, Chen Y, Wang Q, Pi P, Li J, Lin X, Zhang X, Zhang Y,  Ye J, Restoration of mRNA Expression of Solute Carrier Proteins in Liver of Diet-Induced Obese Mice by Metformin. Front Endocrinol (Lausanne), 2021. 12: p. 720784. (IF=5.5)

        3. Zhong G, Zhang J, Guo Y, Wang Y, Wu M, Ren J, Li Y, Zhang X, Zhou B, Zhao W, Lou Y, Wang H, and Ye J, IF1 inactivation attenuates experimental colitis through downregulation of neutrophil infiltration in colon mucosa. Int Immunopharmacol, 2021. 99: p. 107980. (IF=4.9)

        4. Lijun Yin, Man Luo, Ru Wang, Jianping Ye, Xiaohui Wang,Mitochondria in Sex Hormone-Induced Disorder of Energy Metabolism in Males and Females. Frontiers in Endocrinology, 2021. 12(1720). (IF=5.5)

        5. Shiqiao Peng, Xiaoying Zhang, Lili Yu, Yanhong Xu, Yang Zhou, Shengnan Qian, Xinyu Cao, Xiaotong Ye, Jiajun Yang, Weiping Jia, Jianping Ye,NF-κB regulates brown adipocyte function through suppression of ANT2. Acta Pharmaceutica Sinica B, 2021 (Published online, https://www.sciencedirect.com/science/article/pii/S2211383521004263).(IF=11.5)

        6. Lin-jian Wang, Peipei Lv, Yongli Lou, Jianping Ye,Gene Expression-based Predication of RNA Pseudouridine Modification in Tumor Microenvironment and Prognosis of Glioma Patients. Frontiers in Cell and Developmental Biology (Accepted on  Dec. 22, 2021) (IF=6.7).

        7. Jin X, Wang Y. Mechanisms of Adiponectin in Regulation of Proinflammatory Cytokine Production and Migration in Macrophages. J Inflamm Res. 2021 Mar 22;14:981-993. IF6.9

                8. Chu Q, Zhu K, Bai Y, Shang H, Zhang D, Zhao M, Zheng P, Jin X. A Single Low Dose of Dexmedetomidine Efficiently Attenuates Esketamine-Induced Overactive Behaviors and Neuronal Hyperactivities in Mice. Front Hum Neurosci. 2021 Oct 12;15:735569.IF3.1  


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      扒开新婚少妇双腿挺进,扒开双腿疯狂进出爽爽爽动,扒开双腿猛进入小柔校花_高清